Seth Godin’s blog has a list of The top 1,000 things to know.
Actually, he only lists the top 20, but they’re pretty good. I saw this guy speak live at a gathering in New York a couple of years ago, and he was entertaining, but seemed to be talking a load of crap in areas where I’m actually knowledgeable. Nonetheless he has a lot of interesting ideas. (He’s the author of Unleashing the Idea Virus, one of the first new books to be given away free on-line as an e-book.)